Abstract #1146

129Xe pulmonary gas exchange spectroscopy in idiopathic pulmonary fibrosis

Scott H. Robertson^1,2, Elianna A. Bier^1,2, Rohan S. Virgincar^1,3, and Bastiaan Driehuys^1,2,3,4

¹Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³Department of Biomedical Engineering, Duke University, Durham, NC, United States, ⁴Department of Radiology, Duke University Medical Center, Durham, NC, United States

Accurately characterizing the chemical shifts of ¹²⁹Xe in the lung, enables probing pulmonary gas exchange at the micron scale interface between the alveoli and capillary beds. Doing so requires decomposing the dissolved phase ¹²⁹Xe spectrum. Whereas previous work identified only two dissolved-phase ¹²⁹Xe resonances associated with blood and barrier tissues, we now employ improved non-linear fitting techniques to decompose complex FIDs into three resonances. This enables us to report updated ratios of ¹²⁹Xe uptake in blood and barrier resonances, many of which differ significantly between control and IPF groups.

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