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Abstract #1147

Assessing Functional Changes in Lungs with Idiopathic Pulmonary Fibrosis using Hyperpolarized Xenon-129 MRI

Kun Qing1, Borna Mehrad1, John P. Mugler, III1, Kai Ruppert1,2, Jaime F. Mata1, Nicholas J. Tustison1, Steven Guan1, Y. Michael Shim1, Iulian C. Ruset3, F. William Hersman3,4, and Talissa A. Altes1,5

1University of Virginia, Charlottesville, VA, United States, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Xemed LLC, Durham, NH, United States, 4University of New Hampshire, Durham, NH, United States, 5University of Missouri, Columbia, MO, United States

Idiopathic pulmonary fibrosis (IPF) is a fatal disease leading to 40,000 deaths each year in the US. Current clinical tools are remarkably limited in their ability to discriminate between subsets of IPF patients. In this study, we demonstrated the ability of a recently developed imaging tool, hyperpolarized xenon-129 MRI, to detect pulmonary physiology highly relevant to pathology found in IPF with 3-D resolution. Xenon-129 MRI may represent a novel tool that can detect previously unrecognized subsets of patients with IPF relevant to treatment and prognosis of this disease.

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