Abstract #1147

Assessing Functional Changes in Lungs with Idiopathic Pulmonary Fibrosis using Hyperpolarized Xenon-129 MRI

Kun Qing¹, Borna Mehrad¹, John P. Mugler, III¹, Kai Ruppert^1,2, Jaime F. Mata¹, Nicholas J. Tustison¹, Steven Guan¹, Y. Michael Shim¹, Iulian C. Ruset³, F. William Hersman^3,4, and Talissa A. Altes^1,5

¹University of Virginia, Charlottesville, VA, United States, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ³Xemed LLC, Durham, NH, United States, ⁴University of New Hampshire, Durham, NH, United States, ⁵University of Missouri, Columbia, MO, United States

Idiopathic pulmonary fibrosis (IPF) is a fatal disease leading to 40,000 deaths each year in the US. Current clinical tools are remarkably limited in their ability to discriminate between subsets of IPF patients. In this study, we demonstrated the ability of a recently developed imaging tool, hyperpolarized xenon-129 MRI, to detect pulmonary physiology highly relevant to pathology found in IPF with 3-D resolution. Xenon-129 MRI may represent a novel tool that can detect previously unrecognized subsets of patients with IPF relevant to treatment and prognosis of this disease.

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