Abstract #1176

Vessel-size dependent response of human cerebral arteries to hyperoxia

Esther AH Warnert¹, Ian D Driver¹, Joseph Whittaker¹, and Kevin Murphy¹

¹Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom

Due to the potential of using hyperoxia as a treatment for cerebral ischemic diseases, including stroke, it is important to fully understand the effects of hyperoxia on the cerebrovasculature. Although it is known that breathing of 100% O₂ leads to a decrease in cerebral blood flow, it is unclear where along the cerebral arterial tree vasoconstriction occurs. Here we show that, while there is expected constriction of the large arteries, smaller and more distal arteries actually show vasodilation upon hyperoxia.

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