Abstract #1178

Regional Brain Iron Mapping in Patients with Obstructive Sleep Apnea Syndrome

Sudhakar Tummala¹, Daniel W Kang², Bumhee Park¹, Ruchi Vig¹, Mary A Woo³, Ronald M Harper^4,5, and Rajesh Kumar^1,5,6,7

¹Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²Medicine, University of California at Los Angeles, Los Angeles, CA, United States, ³UCLA School of Nursing, Los Angeles, CA, United States, ⁴Neurobiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States, ⁶Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, ⁷Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States

OSA subjects show brain injury in multiple areas, which may contribute to accumulation of iron in those sites. Deposition of iron in OSA subjects is unclear. We examined regional iron deposition using T2*-relaxometry procedures; R2* values were significantly increased in insular, parietal, cingulate and cingulum bundle, temporal, and cerebellar areas. The increased iron depositions in OSA subjects may result from neural and white matter injury, including myelin and glial dysfunction, with iron potentially accelerating tissue degeneration. These data suggest that interfering with the iron action may reduce the exacerbation of injury in OSA.

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