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Abstract #1179

Measurement of Brain Asymmetry on 3D Magnetic Resonance (MR) Images Obtained for 16 Subjects with Situs Inversus

X. Li1, Neil Roberts1, M. Perrins1, and G. Vingerhoets2

1University of Edinburgh, Edinburgh, United Kingdom, 2Department of Experimental Psychology, Ghent University, Ghent, Belgium

The human brain is structurally asymmetric and typically described as if it has been subject to a rotational moment about the vertical axis of the body, the so-called “Yakovlevian Torque”. In subjects with situs inversus totalis (SI) the internal organs of the body are transposed and it has been obvious to question whether in these subjects brain torque is also reversed? We recruited 16 subjects with SI and 16 age, sex and education matched controls (SS) and applied state of the art image analysis techniques to investigate the extent to which brain asymmetry is reversed on 3D MR images in these subjects. Analysis of the frontal and occipital petalia has confirmed previous reports of significant reversal of the latter but not the former on average in SI, and has also shown that reversed asymmetry is not present in all individuals with SI.

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