Abstract #1186

Increased Glutamate in Frontal Lobe of HIV Infected Patients with CNS involvement: 3T MRS Study

Virendra Kumar¹, Devender Bairwa², Surabhi Vyas³, Achal Srivastava⁴, Bimal K Das⁵, R. M. Pandey⁶, S. K. Sharma², Sanjeev Sinha², and N. R. Jagannathan¹

¹Department of NMR, All India Institute of Medical Sciences, New Delhi, India, ²Department of Medicine, All India Institute of Medical Sciences, New Delhi, India, ³Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, ⁴Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, ⁵Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India, ⁶Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

We investigated the effect of HIV infection status on brain metabolites in HIV patients with CNS involvement and asymptomatic HIV patients. 71 subjects were studied including HIV patients with CNS involvement, asymptomatic HIV patients and healthy controls. Single voxel MRS was carried out at 3.0 Tesla MR scanner and metabolite concentrations were determined from three brain regions; left frontal, left basal ganglia and lesion in case of HIV patients with CNS involvement. Glx (Glu+Gln) and creatine were significantly increased in HIV patients in frontal region compared to healthy controls. The concentration of N-acetylaspartate in basal ganglia showed a significant decrease in HIV patients.

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