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Abstract #1186

Increased Glutamate in Frontal Lobe of HIV Infected Patients with CNS involvement: 3T MRS Study

Virendra Kumar1, Devender Bairwa2, Surabhi Vyas3, Achal Srivastava4, Bimal K Das5, R. M. Pandey6, S. K. Sharma2, Sanjeev Sinha2, and N. R. Jagannathan1

1Department of NMR, All India Institute of Medical Sciences, New Delhi, India, 2Department of Medicine, All India Institute of Medical Sciences, New Delhi, India, 3Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, 4Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, 5Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India, 6Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

We investigated the effect of HIV infection status on brain metabolites in HIV patients with CNS involvement and asymptomatic HIV patients. 71 subjects were studied including HIV patients with CNS involvement, asymptomatic HIV patients and healthy controls. Single voxel MRS was carried out at 3.0 Tesla MR scanner and metabolite concentrations were determined from three brain regions; left frontal, left basal ganglia and lesion in case of HIV patients with CNS involvement. Glx (Glu+Gln) and creatine were significantly increased in HIV patients in frontal region compared to healthy controls. The concentration of N-acetylaspartate in basal ganglia showed a significant decrease in HIV patients.

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Abstract