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Abstract #1195

Disruption of the Relationship between Default Mode Network Connectivity and Task-related Deactivation in Patients with Mild Traumatic Brain Injury

David Yen-Ting Chen1,2, Yi-Tien Li1,3, Chien-Yuan Eddy Lin4,5, Chi-Jeng Chen1, and Ying-Chi Tseng1

1Department of Radiology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, 2Brain and Consciousness Research Center, Taipei Medical University, Taipei City, Taiwan, 3Institute of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan, 4GE Healthcare, Taipei City, Taiwan, 5MR Advanced Application and Research Center, GE Healthcare, Beijing City, China, People's Republic of

Mild traumatic brain injury (MTBI) may cause disruption of default mode network (DMN) in patients. We found differences in both resting state DMN connectivity and task-related deactivation between MTBI patients and healthy controls. Although no significant within-network difference was found in the DMN connectivity between patients and controls, there was increased extra-network connection to the left inferior frontal gyrus in the patients. Significantly more profound task-related deactivation was found in the patients, especially in bilateral IPCs. Increased task-related deactivation may imply the patients need more attention on performing the WM tasks. Furthermore, significant correlation between resting state connectivity and task-related deactivation of DMN was found in healthy controls and this rest-task correlation was disrupted in the patients.

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