Abstract #1196

mTBI symptom severity is associated with functional connectivity of specific networks

Suresh Emmanuel Joel¹, Radhika Madhavan¹, Rakesh Mullick¹, Sumit Niogi², John A Tsiouris², Luca Marinelli³, and Teena Shetty⁴

¹Diagnostic Imaging and Biomedical Technologies, General Electric Global Research, Bangalore, India, ²Weill Cornell Medical College, New York, NY, United States, ³Diagnostic Imaging and Biomedical Technologies, General Electric Global Research, Niskayuna, NY, United States, ⁴Hospital for Special Surgery, New York, NY, United States

Patients who suffer from mild traumatic brain injury (mTBI) have cognitive and behavioral deficits though MR and CT appear normal. Functional neuroimaging has high promise to provide biomarkers which may enable better prognosis and therapy of mTBI. The work here shows in a large sample (78 mTBI patients and 26 controls in 3 sessions spanning 3 months from injury), significant correlation between functional connectivity in visual, motor and default mode networks and self-reported symptom scores. Given this association, functional connectivity stands to be an important contributor to predict mTBI outcome.

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