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Abstract #1197

Resting-state functional connectivity reveals age-related difference in Valproate-induced rat autism model

Hsin-Yi Lai1, Hui-Ching Lin2,3, Hui-Yu Wang4, Jun-Cheng Weng5, Han-Fang Wu2, and You-Yin Chen4

1Interdisciplinary Institute of Neuroscience and Technology (ZIINT), Zhejiang University, Hangzhou City, China, People's Republic of, 2Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan, 3Brain Research Center, National Yang Ming University, Taipei, Taiwan, 4Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, 5Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan

This study demonstrates changes of functional connectivity in motor related brain areas and it is age-related different in Valproate-induced rat autism model. Our results indicate that the motor cortex and striatum may be crucial areas for treatment and evolution of ASD. rsfMRI has potential to explore functional connectivity in the brain and monitor functional plasticity changes in a specific neuroanatomical pathway in vivo.

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