Abstract #1197

Resting-state functional connectivity reveals age-related difference in Valproate-induced rat autism model

Hsin-Yi Lai¹, Hui-Ching Lin^2,3, Hui-Yu Wang⁴, Jun-Cheng Weng⁵, Han-Fang Wu², and You-Yin Chen⁴

¹Interdisciplinary Institute of Neuroscience and Technology (ZIINT), Zhejiang University, Hangzhou City, China, People's Republic of, ²Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan, ³Brain Research Center, National Yang Ming University, Taipei, Taiwan, ⁴Department of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, ⁵Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan

This study demonstrates changes of functional connectivity in motor related brain areas and it is age-related different in Valproate-induced rat autism model. Our results indicate that the motor cortex and striatum may be crucial areas for treatment and evolution of ASD. rsfMRI has potential to explore functional connectivity in the brain and monitor functional plasticity changes in a specific neuroanatomical pathway in vivo.

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