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Abstract #1199

Impaired small-world structural brain network in patients with neuropsychiatric systemic lupus erythematosus

Xiaopei Xu1, Henry KF Mak1, MY Mok2, CS Lau2, and Edward S Hui1

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

To better understand the underlying mechanisms for various neuropsychiatric symptoms in patients with neuropsychiatric systemic lupus erythematosus (NPSLE), we used DTI-based tractography and graph theory approaches to investigate the change in the global configuration and nodal characteristics of the structural brain network in NPSLE and SLE patients. Our results showed impaired small-world structural network and diminished role of several brain regions as hubs in NPSLE patients, indicating the disruption of brain architecture underlying multiple neuropsychiatric manifestations present in NPSLE. Our results demonstrated that brain network analysis is a reliable method to study systemic disease like NPSLE.

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