Abstract #1203

Altered structural network connectivity in non-neuropsychiatric systemic lupus erythematosus: a graph theoretical analysis

Man Xu¹, Xiangliang Tan², Patrick Peng GAO³, Ed.X. Wu^3,4, Yingjie Mei^1,5, Xixi Zhao², Yikai Xu², and Yanqiu Feng^1,3,4

¹School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, People's Republic of, ²Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ³Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, People's Republic of, ⁴Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, People's Republic of, ⁵Philips Healthcare, Guangzhou, China, People's Republic of

The character of the brain structural connectivity in patients with non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has not been well studied. The aim of the study was to investigate the alterations of the topological metrics in non-NPSLE networks and to identify the regions in which the metrics were significantly different. A structural connectivity matrix was constructed for each subject using PANDA toolbox. Then graph theoretical analysis was applied to investigate the alteration of the metrics. The results revealed that the non-NPSLE group exhibited a trend of decreased global network properties and changed betweenness and degree in several brain regions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.