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Abstract #1202

Network centrality insights into the effects of Dexamethasone on brain function in healthy subjects

Fatima Nasrallah1,2,3, Bernice OH4, Trina Kok2, Mary Stephenson2, Tony Chin-Ian Tay4, Edwin Kean-Hui Chiew4, Jiesen Wang5, Alexandre Schaefer5, Adriana Benzoic5, Johnson Fam4, and Allen Eng-Juh Yeoh4

1Clinical Imaging Research Centre, NUS/A*STAR, St Lucia, Australia, 2Clinical Imaging Research Centre, NUS/A*STAR, Singapore, Singapore, 3Queensland Brain Institute, Queensland, Australia, 4National University Hospital, Singapore, Singapore, 5Clinical Imaging Research Centre, NUS, Singapore, Singapore

Dexamethasone is a glucocorticoid which has demonstrated clinical improvement in acute lymphoblastic leukaemia patients but has been associated with diminished memory and executive function. Because it is normally administered as a cocktail of drugs during the treatment regimen, understanding its main mechanism of action has been hindered. We investigate the effect of dexamethasone on brain function in healthy volunteers using resting state fMRI connectivity

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