Abstract #1202

Network centrality insights into the effects of Dexamethasone on brain function in healthy subjects

Fatima Nasrallah^1,2,3, Bernice OH⁴, Trina Kok², Mary Stephenson², Tony Chin-Ian Tay⁴, Edwin Kean-Hui Chiew⁴, Jiesen Wang⁵, Alexandre Schaefer⁵, Adriana Benzoic⁵, Johnson Fam⁴, and Allen Eng-Juh Yeoh⁴

¹Clinical Imaging Research Centre, NUS/A*STAR, St Lucia, Australia, ²Clinical Imaging Research Centre, NUS/A*STAR, Singapore, Singapore, ³Queensland Brain Institute, Queensland, Australia, ⁴National University Hospital, Singapore, Singapore, ⁵Clinical Imaging Research Centre, NUS, Singapore, Singapore

Dexamethasone is a glucocorticoid which has demonstrated clinical improvement in acute lymphoblastic leukaemia patients but has been associated with diminished memory and executive function. Because it is normally administered as a cocktail of drugs during the treatment regimen, understanding its main mechanism of action has been hindered. We investigate the effect of dexamethasone on brain function in healthy volunteers using resting state fMRI connectivity

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