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Abstract #1201

Thalamocortical network alteration in Children and Adolescents with Idiopathic Generalized Epilepsy

Tijiang Zhang1, Wuchao Li1, Quanzhong Zhou1, Ganjun Song1, Cong Tian1, Zhen Zeng1, and Xingyu Wang1

1Department of Radiology, Affiliated hospital of Zunyi Medical College, Zunyi, China, People's Republic of

The aim of this study is to investigate FC alterations of thalamocortical network using resting-state fMRI,and correlation FC alterations with Intelligence Quotient (IQ) . 19 patients and 19 healthy volunteers took part in this research. The thalamocortical FC seeding at the left thalamus in the IGE patients showed a significant increase in left inferior temporal gyrus and right supramarginal gyrus, but decrease in left anterior cingulate, bilateral posterior cingutate, bilateral dorsolateral frontal gyrus, whereas, seeding the right thalamus as seed showed increase in right cerebellum, right supramarginal gyrus, but decrease in bilateral dorsolateral frontal gyrus, bilateral PCC and right supramarginal gyrus. Correlation analysis revealed that IQ positively correlated with FC strength between thalamus and left anterior cingulate, left dorsolateral superior frontal gyrus. The alteration of FC may reflect the progress of long-term destruction of functional architecture, and may be served as a potential biomarker to examine subtle brain abnormalities in children and adolescence with IGE.

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