Sheng-Min Huang1, Kun-I Chao1, Kung-Chu Ho2, and Fu-Nien Wang1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Division of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
We investigated the DMN in ADHD rats of
different ages. A major difference of DMN between SHR and WKY rats was found in
caudate putamen area. As age increasing, the striatal activation presented in
the DMN of 6-week SHR started to decrease at 8-week and tend to fade out at
10-week. Since the volume difference of striatal region between SHR and WKY
rats has been reported, our result may suggest that the structural development is
followed by persisted functional network alteration. The correlation of
development of striatal volume and striatal resting state activity both suggest
that the timing is important.
