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Abstract #1207

Altered Default Mode Network in Developmental Stages of ADHD Rats

Sheng-Min Huang1, Kun-I Chao1, Kung-Chu Ho2, and Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Division of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

We investigated the DMN in ADHD rats of different ages. A major difference of DMN between SHR and WKY rats was found in caudate putamen area. As age increasing, the striatal activation presented in the DMN of 6-week SHR started to decrease at 8-week and tend to fade out at 10-week. Since the volume difference of striatal region between SHR and WKY rats has been reported, our result may suggest that the structural development is followed by persisted functional network alteration. The correlation of development of striatal volume and striatal resting state activity both suggest that the timing is important.

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