Abstract #1209

Graph-Theoretical Analysis of BOLD-fMRI Using Nociceptive Stimuli Unravels Characteristics of Pain Chronification

Isabel Wank¹, Silke Kreitz¹, and Andreas Hess¹

¹Institute of Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen, Germany

Pain is a warning sign and a highly potent modulator of behavior. This naturally very useful mechanism evolves into a central healthcare problem, when pain becomes chronic and highly impacting the patient's daily life. By means of fMRI and modern graph theoretical analyses, we surveyed dynamic changes of functional connectivity within the mouse brain evoked within 7 sessions of noxious thermal stimulation of the hind paw. With no evidence of peripheral hyperalgesia, we found noticeable alterations of connectivity especially within cognitive and associative-evaluative brain structures. We hypothesize that these findings reflect profound changes that central sensitization impresses on the brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.