Abstract #1210

Quantitative sodium MRI in traumatic brain injury (TBI): Pilot study

Guillaume Madelin¹, Jonathan M Silver², Tamara Bushnik³, and Ivan I Kirov¹

¹Department of Radiology, New York University Langone Medical Center, New York, NY, United States, ²Department of Psychiatry, New York University Langone Medical Center, New York, NY, United States, ³Department of Rehabilitation Medicine, New York University Langone Medical Center, New York, NY, United States

In this pilot quantitative sodium MRI study, 4 patients in the chronic stage after traumatic brain injury (TBI) and 6 controls were scanned at 3 T. Intracellular sodium concentration (C₁) and extracellular volume fraction (α₂) were calculated in lesions, as well as in whole grey and white matters. Global C₁ skewness and kurtosis showed significant differences between patients and controls, and regional measurements in lesions presented large increases of C₁ and α₂ compared to normal tissue. The results indicate that quantitative sodium MRI shows promise as an imaging biomarker of cell death in chronic TBI.

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