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Abstract #1211

GlucoCEST matches 18F-FDG PET on a pulse focus ultrasound induced traumatic brain injury

Tsang-Wei Tu1, Zsofia I. Kovacs1, George Z. Papadakis1, Neekita Jikaria1, William Reid1, Dima Hammoud 1, and Joseph A. Frank1

1Radiology and Imaging Sciences, National Institute of Health, Bethesda, MD, United States

18F-FDG positron emission tomography (PET) is used to non-invasively measure the glucose metabolism in the brain. However PET imaging is also limited on the longitudinal monitoring of glucose due low spatial and anatomical resolution. This study compares the glucoCEST and 18F-FDG PET in detecting the glucose concentration in a new traumatic brain injury model using MRI guided pulsed focus ultrasound. Our data show that the glucoCEST could deliver comparable results with the 18F-FDG PET results in detecting the event of hypo-metabolism in the traumatized brain with greater higher image resolution as compared to PET scans.

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