Abstract #1212

Therapeutic potential of mesenchymal stem cells after transplantation in traumatic brain injury mice: an in vivo 1H MRS and behavioural study

Sushanta Kumar Mishra^1,2, Subash Khushu¹, and Gurudutta Gangenahalli²

¹NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi, India, ²Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Mesenchymal stem cells have been shown to be effective against neuronal degeneration through mechanisms that include both the recovery of neurometabolites and behavioural activity. This study demonstrates that intravenous administration of MSCs in traumatic brain injury mice alter the neurometabolic concentration at lesion site and improve the behavioural functional outcome. The concentrations of metabolites like phosphocholine and inositol were increased, while other metabolites like NAA, GABA, Cr+PCr, Glu+Gln and taurine were decreased at injury site after MSCs transplantation and become its normal concentrations. The functional activities like stress level, grip strength and depression index were improved in transplanted TBI mice.

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