Abstract #1218

Quantitative Tissue Specific R2* Measurements detect mTBI related damage in brain areas without evident anatomical changes

Jie Wen¹, Serguei V. Astafiev², Kristina L. Zinn², Anne H. Cross², Dmitriy A. Yablonskiy¹, and Maurizio Corbetta²

¹Radiology, Washington University, Saint Louis, MO, United States, ²Neurology, Washington University, Saint Louis, MO, United States

In this study we used quantitative tissue specific R2* measurements to detect brain abnormalities in chronic subjects with mild traumatic brain injury (mTBI). mTBI patients demonstrated decreased R2* values in frontal pole and hippocampus. Reduced R2* values in the white matter of the hippocampus were strongly related to the reported memory problems typical for mTBI. Importantly, this R2* value reduction was not accompanied by decreased volume of white matter and grey matter inside those regions, suggesting that R2* values may detect mTBI related abnormalities before detectable anatomical changes appear.

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