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Abstract #1218

Quantitative Tissue Specific R2* Measurements detect mTBI related damage in brain areas without evident anatomical changes

Jie Wen1, Serguei V. Astafiev2, Kristina L. Zinn2, Anne H. Cross2, Dmitriy A. Yablonskiy1, and Maurizio Corbetta2

1Radiology, Washington University, Saint Louis, MO, United States, 2Neurology, Washington University, Saint Louis, MO, United States

In this study we used quantitative tissue specific R2* measurements to detect brain abnormalities in chronic subjects with mild traumatic brain injury (mTBI). mTBI patients demonstrated decreased R2* values in frontal pole and hippocampus. Reduced R2* values in the white matter of the hippocampus were strongly related to the reported memory problems typical for mTBI. Importantly, this R2* value reduction was not accompanied by decreased volume of white matter and grey matter inside those regions, suggesting that R2* values may detect mTBI related abnormalities before detectable anatomical changes appear.

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