Abstract #1217

Assessment of mild traumatic brain injury due to blast overpressure in breachers: A 31P MRS Study.

Mary C Stephenson^1,2, Trina Kok¹, Fatima A Nasrallah¹, Pamela Boon Li Pun³, Melissa Ai Ling Teo³, Julie Su Li Yeo³, Lu Jia³, Benjamin A Thomas¹, Mary K Enci³, and John J Totman¹

¹Clinical Imaging Research Centre, A*STAR-NUS, Singapore, Singapore, ²Department of Medicine, NUS, Singapore, Singapore, ³Defense Science Organization, Singapore, Singapore

Traumatic Brain Injury (TBI) is identified as the signature injury of soldiers involved in the Iraq and Afghanistan wars. Mild TBI (mTBI) often goes undetected, meaning vital opportunities for early treatment are missed. In this study we use ³¹P MRS to investigate whether changes in ³¹P metabolites can be identified in soldiers at risk of mTBI due to blast overpressure. Measurements of brain volumes and 31P MRS are made at baseline and 1, 3, 7 and 28 days following training with low level explosives. We show a tendency for decreases in Pi/PCr ratio which reach significance 28 days after training.

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