Abstract #1216

Distribution of brain sodium after mild traumatic brain injury

Yvonne W Lui¹, Yongxian Qian¹, Karthik Lakshmanan¹, Jacqueline Smith¹, Graham Wiggins¹, Steven Flanagan², and Fernando E Boada¹

¹Radiology, New York University, New York, NY, United States, ²Rehabilitation Medicine, New York University, New York, NY, United States

Mild traumatic brain injury (mTBI) is a growing public health problem with more than 1.5 million cases a year in the United States. The pathophysiological processes underlying mTBI are complex, including biomechanical injury induced stretching of the axons and depolarization of the normal resting voltage across the cell membrane. Sodium handling by the brain is critical to restore ionic homeostasis after injury and disordered handling is implicated in the long-term pathophysiology of concussion. With state-of-the-art sodium (23Na) MR imaging, one can obtain high quality sodium images in a clinical setting at 3T. Here we seek to observe patterns of total sodium distribution in brain in individuals with mTBI.

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