Abstract #1223

Tract-based Spatial Statistics of DTI Metrics in Parkinson's Disease

Yong Zhang¹, Hailong Luo², Changzheng Shi², and Li Guo³

¹GE Healthcare MR Research China, Beijing, China, People's Republic of, ²Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China, People's Republic of, ³Neurology, the First Affiliated Hospital of Jinan University, Guangzhou, China, People's Republic of

Tract-based spatial statistics of average and directional DTI-derived metrics were analyzed between the Parkinson's patients and age-matched healthy controls. It was found that MD increased and FA decreased across WM in accordance with previous studies. The more widespread change of MD compared with FA suggests higher sensitivity of MD to WM degenerations. Besides, it was observed that the change of perpendicular diffusivity was more profound compared with that of axial diffusivity, suggesting the existence of demyelination in PD patients

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