Abstract #1222

Quantitative Susceptibility Mapping (QSM) detects iron deposition and demyelination in mouse model of Huntington Disease

Xuan Vinh To¹, Hongjiang Wei², Reshmi Rajendran¹, Marta Garcia-Miralles³, Ling Yun Yeow¹, Chunlei Liu², Hong Xin¹, Mahmoud A. Pouladi³, and Kai-Hsiang Chuang¹

¹Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore, ²Brain Imaging and Analysis Center, School of Medicine, Duke University, Durham, NC, United States, ³Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

This study looked at the potential for Quantitative Susceptibility Mapping (QSM) for longitudinal detection of demyelination and iron accumulation in YAC128 mouse model of Huntington disease. Control and YAC128 mice were scanned at 9, 12, and 15 months of age; with a number of mice sacrificed after each timepoint for histological validation and correlation (ongoing). Current results shows the potential for QSM in detecting demyelination is several white matter regions and iron accumulation in grey matter.

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