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Abstract #1231

γ-aminobutyric acid spectroscopy of the thalamus in diabetic neuropathy

Iain D Wilkinson1, Pillai Shillo1, Marni Greig1, Solomon Tesfaye1, Richard A Edden2, and Dinesh Selvarajah1

1Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Kennedy Krieger Institute, Baltimore, MA, United States

The sensory system is affected in diabetic neuropathy (DN), a common ailment associated with diabetes mellitus. The thalamus is part of the brain’s sensory pathway. This study applies MEGA-PRESS to assess thalamic GABA in-vivo in patients with and without DN. Differences in GABA/H20 ratios were identified between those with and without DN, demonstrating potential differences in the neuronal inhibitory status of the thalamus.

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