Iain D Wilkinson1, Pillai Shillo1, Marni Greig1, Solomon Tesfaye1, Richard A Edden2, and Dinesh Selvarajah1
1Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Kennedy Krieger Institute, Baltimore, MA, United States
The sensory system is affected in diabetic neuropathy (DN), a common
ailment associated with diabetes mellitus. The thalamus is part
of the brain’s sensory pathway.
This
study applies MEGA-PRESS to assess thalamic GABA in-vivo in patients with and
without DN. Differences
in GABA/H20 ratios were identified between those with and without DN,
demonstrating potential differences in the neuronal inhibitory status of the
thalamus.
