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Abstract #1230

Associations between Brain Microstructural and Motor Severity of Parkinsonian Symptoms in Elderly Parkinson Diseases

MohammadHadi Aarabi1, Farzaneh Rahmani1, Ahmad Shojaei2, and Hamidreza Safabakhsh2

1Students'Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran, 2Basir Eye Health Research Center, Tehran, Iran., Tehran, Iran

Parkinson's Disease (PD) is a progressive neurodegenerative disorder assumed to involve different areas of CNS and PNS. Thus, Diffusion Tensor Imaging (DTI) is used to examine the areas engaged in PD neurodegeneration. We studied the relationship between local connectome alterations obtained by connectometry approach and motor severity of elderly PD as measured with Unified Parkinson's disease 3. Our findings demonstrate the fornix and cingulium fibers in limbic system have association with motor severity in elderly PD patients in onset.

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