Abstract #1229

Comparison of Thalamic GABA and Glx Levels in Patients with Essential Tremor and Parkinson's Disease

Ruoyun Ma^1,2, Johnathan P Dyke³, Shalmali Dharmadhikari⁴, Nora Hernandez⁵, Elizabath Zauber⁶, Elan Louis^5,7,8, and Ulrike Dydak^1,2

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ³Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ⁵Department of Neurology, Yale School of Medicine, New Heaven, CT, United States, ⁶Department of Neurology, Indianapolis University School of Medicine, Indianapolis, IN, United States, ⁷Department of Chronic Disease Epidemiology, Yale School of Public Health, New Heaven, CT, United States, ⁸Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, New Heaven, CT, United States

Essential tremor (ET) and Parkinson’s disease (PD) are two most prevalent movement disorders. It was suggested that tremors in both diseases, though of different types, may be modulated by neuropathways involving the thalamus. We found a significant trend of elevated thalamic GABA levels from controls to ET patients to PD patients, which may be related to the increased risk of ET patients to develop PD, and thus suggesting thalamic GABA as imaging marker of preclinical parkinsonism. However, thalamic GABA is not associated with tremor of either type.

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