We used MRI IVIM technique to
investigate how is microstructure in cortical gray matter (CGM) affected by
white matter hyperintensity (WMH), and how does it affect cognitive function.
We found that diffusion in WMH is correlated with diffusion in CGM. And
diffusion in CGM is connected with cognitive state, while diffusion in WMH isn’t.
This may suggest that CGM damage is secondary to microstructural damage in WMH.
And CGM damage may lead to cognitive dysfunction， while WMH can
only affect cognitive state by damaging gray matter.