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Abstract #1235

Regional specificity of obesity-induced neurochemical modifications measured in vivo by proton MRS at 14.1 T

João M.N. Duarte1, Blanca Lizarbe1, Rolf Gruetter1,2,3, and Ana Francisca Soares1

1LIFMET, EPFL, Lausanne, Switzerland, 2UNIL, Lausanne, Switzerland, 3UNIGE, Geneva, Switzerland

Insulin resistance has deleterious effects on memory performance, brain morphology and the neurochemical profile of the cortex and hippocampus. We now investigated the neurochemical modifications in the hippocampus, cortex and hypothalamus of mice exposed to high-fat diet, a model of obesity-associated insulin resistance. In long-term high-fat diet-exposed mice, obesity-associated insulin resistance affects the neurochemical profiles of the hippocampus, cortex and hypothalamus in a region-specific manner.

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