Ryoko Yamamori1, Tosiaki Miyati1, Naoki Ohno1, Mitsuhito Mase2, Tomoshi Osawa2, Shota Ishida1, Hiroto Kan3, Nobuyuki Arai3, Harumasa Kasai3, and Yuta Shibamoto3
1Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 2Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 3Department of Radiology, Nagoya City University Hospital, Nagoya, Japan
Apparent diffusion
coefficient (ADC) in brain significantly changed during the cardiac cycle, and
this change (ΔADC) in patients with idiopathic normal pressure hydrocephalus
(iNPH) characterized by low intracranial compliance was significantly higher
than those in control subjects. Shunt surgery is the most common treatment for
iNPH. In this study, we determined and compared ΔADC values of the white matter
in iNPH before and after shunt surgery. ΔADC in the frontal white
matter decreases with the shunt surgery. ΔADC analysis makes it possible
to noninvasively provide detailed information on change in the intracranial
condition due to the shunt surgery.
