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Abstract #1236

ΔADC in Idiopathic Normal Pressure Hydrocephalus After Shunt Surgery

Ryoko Yamamori1, Tosiaki Miyati1, Naoki Ohno1, Mitsuhito Mase2, Tomoshi Osawa2, Shota Ishida1, Hiroto Kan3, Nobuyuki Arai3, Harumasa Kasai3, and Yuta Shibamoto3

1Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 2Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 3Department of Radiology, Nagoya City University Hospital, Nagoya, Japan

Apparent diffusion coefficient (ADC) in brain significantly changed during the cardiac cycle, and this change (ΔADC) in patients with idiopathic normal pressure hydrocephalus (iNPH) characterized by low intracranial compliance was significantly higher than those in control subjects. Shunt surgery is the most common treatment for iNPH. In this study, we determined and compared ΔADC values of the white matter in iNPH before and after shunt surgery. ΔADC in the frontal white matter decreases with the shunt surgery. ΔADC analysis makes it possible to noninvasively provide detailed information on change in the intracranial condition due to the shunt surgery.

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