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Abstract #1237

Magnetic susceptibility in primary motor cortex correlates with iron concentration and upper motor neuron impairment in amyotrophic lateral sclerosis

Mauro Costagli1, Graziella Donatelli2, Laura Biagi3, Elena Caldarazzo Ienco2, Gabriele Siciliano2, Michela Tosetti3, and Mirco Cosottini2

1Imago7, Pisa, Italy, 2University of Pisa, Pisa, Italy, 3IRCCS Stella Maris, Pisa, Italy

3D gradient-recalled multi-echo sequences were used on a 7 Tesla MR system for Quantitative Susceptibility Mapping (QSM) targeting M1 at high spatial resolution in patients with Amyotrophic Lateral Sclerosis (ALS) and Healthy Controls (HC). The magnetic susceptibility of the deep cortical layers of patients’ M1 subregions corresponding to Penfield's areas of the hand and foot significantly correlated with the clinical scores of UMN impairment. QSM might therefore prove useful in measuring M1 iron concentration, as a possible in vivo biomarker of UMN burden and neuroinflammation in ALS patients.

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