Abstract #1239

White matter connectome in patients with genetic dystonia

Silvia Basaia¹, Federica Agosta¹, Alexandra Tomic², Elisabetta Sarasso¹, Nikola Kresojević², Sebastiano Galantucci¹, Marina Svetel², Vladimir S. Kostic², and Massimo Filippi^1,3

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Yugoslavia, ³Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

We investigated structural neural pathways in asymptomatic and symptomatic mutation carriers with several dystonia (DYT) genotypes using a network approach. Both symptomatic and asymptomatic mutation carriers showed an alteration of structural connectivity compared to controls, beyond the basal ganglia/sensorimotor cortex regions. No differences were found between symptomatic and asymptomatic DYT subjects. The structural connectome offered the possibility of identifying genotype-related trait characteristics, even in the preclinical phase of the disease, providing new insights into understanding DYT generation.

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