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Abstract #1240

MEMRI Detects Neuronal Loss in MPTP-Intoxicated Mice.

Aditya N Bade1, Katherine Olson1, Charles Schutt1, Jingdong Dong2, R Lee Mosley1, Howard E Gendelman1, Michael D Boska1,3, and Yutong Liu1,3

1Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Omaha, NE, United States, 2Second Affiliated Hospital, Dalian Medical University, Dalian, China, People's Republic of, 3Department of Radiology, University of Nebraska Medical Center, Omaha, Omaha, NE, United States

This study showed that neuronal loss in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injected mice as confirmed by immunohistology caused signal change in manganese-enhanced MRI (MEMRI). Both gliosis and neuronal loss occur in the progress of neurodegenerative diseases. Previous studies have shown that MEMRI signal is associated with he gliosis in rodents. With the findings in this study, it is demonstrated the combined pathologic effects of neuronal damage and gliosis determine MEMRI results. The study suggested that MEMRI is an in vivo imaging tool to study the progress of neurodegenerative disease in rodents.

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