Abstract #1240

MEMRI Detects Neuronal Loss in MPTP-Intoxicated Mice.

Aditya N Bade¹, Katherine Olson¹, Charles Schutt¹, Jingdong Dong², R Lee Mosley¹, Howard E Gendelman¹, Michael D Boska^1,3, and Yutong Liu^1,3

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Omaha, NE, United States, ²Second Affiliated Hospital, Dalian Medical University, Dalian, China, People's Republic of, ³Department of Radiology, University of Nebraska Medical Center, Omaha, Omaha, NE, United States

This study showed that neuronal loss in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injected mice as confirmed by immunohistology caused signal change in manganese-enhanced MRI (MEMRI). Both gliosis and neuronal loss occur in the progress of neurodegenerative diseases. Previous studies have shown that MEMRI signal is associated with he gliosis in rodents. With the findings in this study, it is demonstrated the combined pathologic effects of neuronal damage and gliosis determine MEMRI results. The study suggested that MEMRI is an in vivo imaging tool to study the progress of neurodegenerative disease in rodents.

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