Abstract #1243

Relationship between hippocampal volume, white matter and cognition in temporal lobe epilepsy

Amanda K.W. Buck^1,2, Lauren M. Severence², Benjamin N. Conrad¹, Bennett A. Landman^1,3, Adam W. Anderson^1,2, Bassel Abou-Khalil⁴, Monica L. Jacobs⁵, and Victoria L. Morgan^1,2

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, ⁴Neurology, Vanderbilt University, Nashville, TN, United States, ⁵Psychiatry, Vanderbilt University, Nashville, TN, United States

Temporal lobe epilepsy (TLE) is associated with changes in regional brain structure, function, and cognition. This study demonstrates an indirect link between right hippocampal volume reductions and extratemporal cognition in right TLE. As hippocampal volume decreases, the right uncinated fasciculus (RUF) axial diffusivity (AD) increases. This increase is correlated with verbal comprehension index (VCI) score decrease. Considering that VCI deficits are related to inferior frontal cortex lesions, these results imply that the RUF, which structurally connects the hippocampus to the frontal lobe, is the mediator of impairment between the seizure focus in the hippocampus and VCI deficits in right TLE.

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