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Abstract #1244

Arterial Spin Labelling perfusion measurements in Prion Disease: relation with restricted diffusion

Enrico De Vita1,2, Andrew Melbourne3, Marie-Claire Porter4,5, David L Thomas6, Sebastien Ourselin3, Tarek Yousry1,2, Xavier Golay2, Rolf Jager1,2, Simon Mead4,5, and John S Thornton1,2

1Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 2Academic Neuroradiological Unit. Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 3Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 4National Prion Clinic, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 5MRC Prion Unit, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom, 6Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom

Perfusion in Prion disease has only been explored with SPECT, except in 2 single-case studies.

We aimed to evaluate perfusion abnormalities with ASL-MRI in prion patients and compare the findings with clinically diagnostic high b-value diffusion weighted MRI. We observed high correlation between diffusion abnormalities and hypoperfusion. ASL-MRI could help to shed light non-invasively on the neurovascular aspects of prion disease

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