Abstract #1244

Arterial Spin Labelling perfusion measurements in Prion Disease: relation with restricted diffusion

Enrico De Vita^1,2, Andrew Melbourne³, Marie-Claire Porter^4,5, David L Thomas⁶, Sebastien Ourselin³, Tarek Yousry^1,2, Xavier Golay², Rolf Jager^1,2, Simon Mead^4,5, and John S Thornton^1,2

¹Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ²Academic Neuroradiological Unit. Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ³Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁴National Prion Clinic, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁵MRC Prion Unit, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom, ⁶Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom

Perfusion in Prion disease has only been explored with SPECT, except in 2 single-case studies.

We aimed to evaluate perfusion abnormalities with ASL-MRI in prion patients and compare the findings with clinically diagnostic high b-value diffusion weighted MRI. We observed high correlation between diffusion abnormalities and hypoperfusion. ASL-MRI could help to shed light non-invasively on the neurovascular aspects of prion disease

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