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Abstract #1245

Superior sensitivity to focal cortical dysplasia obtained by a multivariate analysis of MRI and PET image features

Hosung Kim1, Yee-Leng Sung Tan2, Tarik Tihan3, Anthony James Barkovich1, Duan Xu1, and Robert C Knowlton2

1Radiology & Biomedical Imaging, University california San francisco, San Francisco, CA, United States, 2Neurology, University california San francisco, SAN FRANCISCO, CA, United States, 3Pathology, University california San francisco, SAN FRANCISCO, CA, United States

Focal cortical dysplasia (FCD) is an epileptogenic developmental malformation. Identification of this lesion can lead to a successful surgery. We propose to analyze a combined feature-set extracted from MRI and PET. Studying 29 FCD patients and 23 controls, classification using the combined MRI and PET features demonstrated superior performance to the analysis of MRI as it resulted in a lower false positive (FP) rate in controls (1.3% lower) and a higher sensitivity in FCD (7% higher). Analysis of the combined MRI and PET revealed a larger FP rate in FCD compared to MRI-only, suggesting the presence of extralesional pathology.

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