Abstract #1246

MR-based brain Morphometry Improves Localization of Focal Cortical Dysplasia at Individual Level

Xin Chen¹, Tianyi Qian², Bénédicte Maréchal^3,4,5, Nan Chen¹, and Kuncheng Li¹

¹Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, People's Republic of, ²MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, People's Republic of, ³Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, ⁴LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Swaziland, ⁵Radiology, University Hospital (CHUV), Lausanne, Switzerland

In order to explore the potential of volume-based morphometry for computer-aided diagnosis on an individual level, we evaluated a volume-based morphometric MRI analysis prototype for detection of cortical abnormalities in individual focal cortical dysplasia (FCD) patients for whom no lesion was reported after routine MR exam. Using intracranial EEG as the gold standard, the results of a performed ROC analysis show good detection performance with AUC=0.882, sensitivity =93.88%, and specificity 79.57% at the optimal cut-off point. These results suggest that such automated methods provide additional value for MR-based diagnostics.

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