Abstract #1247

High-quality MRS detects metabolic changes in mice at different stages of prion disease

Eleni Demetriou¹, Mohamed Tachrount², Karin Shmueli³, Mark Farrow⁴, and Xavier Golay¹

¹Brain Repair and Rehabilitation, Institute of Neurology, London, United Kingdom, ²Brain repair and rehabilitation, Institute of Neurology, London, United Kingdom, ³Medical Physics and Biomedical Engineering, University College of London, London, United Kingdom, ⁴MRC prion unit, University College of London, London, United Kingdom

The neurochemical profile of prion disease in mice at different disease stages was evaluated using high-quality MR spectra obtained in thalamus. Seven metabolites were measured in vivo and longitudinally providing substantial metabolic information. Metabolic changes were obtained throughout the disease course, however only glutamate and myo-inositol were significantly different at all stages of the disease. We conclude that MR spectroscopy provides additional information over previous histological studies [1].

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