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Abstract #1248

Alterations Of Functional Connectivity in Resting-State Networks Following Medial Temporal Lobectomy in Patients With Unilateral Hippocampal Sclerosis

Arzu Ceylan Has1, Irsel Tezer2, Burcak Bilginer3, Serap Saygi2, and Kader Karli Oguz4

1National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 2Department of Neurology, Hacettepe University, Ankara, Turkey, 3Department of Neurosurgery, Hacettepe University, Ankara, Turkey, 4Department of Radiology, Hacettepe University, Ankara, Turkey

Temporal lobe epilepsy with unilateral hippocampal sclerosis patients benefit from the medial temporal lobectomy. Since the hippocampus is involved in many cognitive tasks, we hypothesized that resting-state(rs) network alterations would occur in these patients following temporal lobectomy. All patients had pre- and post-operative neurocognitive tests, rs-fMRI and structural T1-weighted imaging . Post-operative studies were performed at 1-year-follow-up. Following temporal lobectomy, left- and right-HS patients showed significantly decreased and increased activations in default-mode-network and fronto-parietal-network. A pre-operative extent of tissue damage or dominancy of the epileptic hemisphere may be responsible for the different patterns of adaptation/change of brain networks after lobectomy.

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