Abstract #1248

Alterations Of Functional Connectivity in Resting-State Networks Following Medial Temporal Lobectomy in Patients With Unilateral Hippocampal Sclerosis

Arzu Ceylan Has¹, Irsel Tezer², Burcak Bilginer³, Serap Saygi², and Kader Karli Oguz⁴

¹National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, ²Department of Neurology, Hacettepe University, Ankara, Turkey, ³Department of Neurosurgery, Hacettepe University, Ankara, Turkey, ⁴Department of Radiology, Hacettepe University, Ankara, Turkey

Temporal lobe epilepsy with unilateral hippocampal sclerosis patients benefit from the medial temporal lobectomy. Since the hippocampus is involved in many cognitive tasks, we hypothesized that resting-state(rs) network alterations would occur in these patients following temporal lobectomy. All patients had pre- and post-operative neurocognitive tests, rs-fMRI and structural T1-weighted imaging . Post-operative studies were performed at 1-year-follow-up. Following temporal lobectomy, left- and right-HS patients showed significantly decreased and increased activations in default-mode-network and fronto-parietal-network. A pre-operative extent of tissue damage or dominancy of the epileptic hemisphere may be responsible for the different patterns of adaptation/change of brain networks after lobectomy.

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