Abstract #1250

Structural and Functional Reorganization of the Rat Brain in the 6-OHDA Model of Parkinson’s Disease

Vincent Perlbarg^1,2, Benjamin Butler³, Justine Lambert³, Romain Valabrègue³, Anne-Laure Privat³, Chantal François³, Stéphane Lehéricy^4,5, and Alexandra Petiet^4,5

¹Bioinformatics and Biostatistics Platform, Brain and Spine Institute, Paris, France, ²UPMC/Inserm UMRS1146 / CNRS UMR7371, Paris, France, ³Brain and Spine Institute, Paris, France, ⁴Center for Neuroimaging Research, Brain and Spine Institute, Paris, France, ⁵UPMC/Inserm UMRS1127 / CNRS UMR7225, Paris, France

Parkinson’s disease (PD) is characterized by neurodegeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc), which can be recapitulated in the 6-hydroxydopamine (6-OHDA) rat model. To evaluate structural and functional cerebral reorganization after induction of the lesion, we performed a longitudinal study up to 6 weeks using diffusion and resting-state functional MRI. Our results showed increased fractional anisotropy in the striatum ipsilateral to the lesion and increased bilateral functional connectivity between the striatum, the globus pallidus and the sensorimotor cortex in the 6-OHDA group. These results will help improve our understanding of cerebral alterations and reorganization in PD pathology.

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