Abstract #1253

Conformity between Brain structures and Neuropsychological tests in Methamphetamine Abusers

Artit Rodkong¹, Nuttawadee Intachai¹, Suwit Saekho^1,2, Apinun Aramrattana³, Kanok Uttawichai⁴, Mekkla Thomson⁵, Bangorn Sirirojn⁶, Daralak Thavornprasit⁶, Sineenart Taejaroenkul⁶, Kamolrawee Sintupat⁶, Victor Valcour⁷, Robert Paul⁸, and Napapon Sailasuta⁹

¹Radiological Technology, Chiang Mai University, Chiang Mai, Thailand, ²Biomedical Engineering Center, Chiang Mai University, Chiang Mai, Thailand, ³Family Medicine, Chiang Mai University, Chiang Mai, Thailand, ⁴Thanyarak Hospital, Chiang Mai, Thailand, ⁵Westat, Rockville, MD, United States, ⁶Research Institute for Health Sciences, Chiang Mai, Thailand, ⁷Neurology, University of California, San Francisco, San Francisco, CA, United States, ⁸Psychology, University of Missouri, St. Louis, MO, United States, ⁹Huntington Medical Research Institute, Pasadena, CA, United States

Magnetic resonance imaging (MRI) studies show evidence of brain alteration in Methamphetamine (MA) users. We compare brain structures including gray matter (GM), white matter (WM) and cortical thickness between MA abusers and Healthy control (HC) group, and explore relationship between brain structures and neuropsychological performance (NP) in MA compared with HC. The results demonstrated that MA group revealed poorer cognitive function and reduced volumetrics in critical brain regions that underlie cognitive performance compared to that of the HC group.

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