Abstract #1254

Modifications of gray matter volume in migraine patients over four years: a tensor-based morphometry study

Elisabetta Pagani¹, Maria Assunta Rocca^1,2, Roberta Messina¹, Bruno Colombo², Giancarlo Comi², Andrea Falini³, and Massimo Filippi^1,2

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ³Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

Aim of the study was to explore longitudinal gray matter (GM) changes over a four-year follow up in migraine patients and their association with patients’ clinical characteristics and disease activity. Brain dual-echo and 3D T1-weighted scans were acquired from 25 patients with migraine and 25 healthy controls at baseline and after 4 years. At follow up, compared to controls, migraine patients had an increased volume of fronto-parietal regions, whereas they developed atrophy of the right thalamus and occipital areas. The migraine brain changes dynamically over time. Various pathophysiological mechanism might affect different brain regions in migraineurs after 4 years.

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