Abstract #1255

3D Texture Analyses of Quantitative Susceptibility Maps to Differentiate Alzheimer’s Disease from Cognitive Normal and Mild Cognitive Impairment

Eo-Jin Hwang¹, Hyug-Gi Kim¹, Chanhee Lee¹, Hak Young Rhee², Chang-Woo Ryu¹, Dal-Mo Yang¹, Tian Liu³, Yi Wang³, and Geon-Ho Jahng¹

¹Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of, ²Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of, ³Biomedical Engineering and Radiology, Cornell University, New York, NY, United States

To investigate QSM textures in the subjects with cognitively normal (CN), mild cognitive impairment (MCI) and Alzheimer’s disease (AD) and to compare the QSM texture results with those of 3D T1W images, 18 elderly CN, 18 MCI, and 18 AD subjects were scanned both 3D multi-echo gradient-echo and 3D T1-weighted sequences. The 1st and 2nd ordered texture parameters of the QSMs and 3DT1W images were calculated and compared among the three subject groups to differentiate the subject groups. Our results suggest that the demyelination effect could be more dominant than the metal accumulations in AD progression.

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