Abstract #1256

Longitudinal DTI detects ApoE isoforms dependent change in white matter

Ling Yun Yeow¹, Xuan Vinh To¹, Xin Hong¹, Boon Seng Wong², and Kai-Hsiang Chuang^1,2

¹Neuro Imaging Group, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore, ²Department of Physiology, National University of Singapore, Singapore, Singapore

To understand the genetic influence of ApoE isoforms on the brain aging, we conducted longitudinal diffusion tensor imaging (DTI) on transgenic mice expressing human ApoE3 (hApoE3) or hApoE4 gene. Mean FA showed a general trend of hApoE4 » WT > hApoE3 from 12 to 18 months of age. There was age-dependent reduction of FA in all the animals, which was due to increased radial diffusivity. The hApoE4 mice also showed larger increase of parallel diffusivity. These indicate ApoE isoform dependent axonal change with aging.

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