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Abstract #1257

Assessment of metabolism, perfusion and diffusion changes in the hippocampal subfields of MCI and AD using simultaneous PET-MR

Maged Goubran1, Audrey Peiwan Fan1, Praveen Gulaka1, David Douglas1, Steven Chao2, Andrew 5 Graduates of Quon1, Greg Zaharchuk1, Minal Vasanawala1, and Michael Zeineh1

1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Neurology, Stanford University, Stanford, CA, United States

Hippocampal subfields are selectively affected in AD, however the hippocampus is assessed as a whole in PET studies. In this work we investigate the metabolic, perfusion and diffusion changes within the subfields of patients with MCI and AD using a simultaneous PET-MR scanner. Our preliminary results demonstrate significant reduction in metabolism and perfusion that are appreciated on the subfield level but not when assessing the hippocampus as a whole. This work suggests that subfield assessment is potentially more sensitive to pathological changes in AD than whole hippocampus analysis, and highlights the utility of simultaneous PET-MR as a tool for discovering novel biomarkers in neurodegenerative diseases.

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