Abstract #1257

Assessment of metabolism, perfusion and diffusion changes in the hippocampal subfields of MCI and AD using simultaneous PET-MR

Maged Goubran¹, Audrey Peiwan Fan¹, Praveen Gulaka¹, David Douglas¹, Steven Chao², Andrew 5 Graduates of Quon¹, Greg Zaharchuk¹, Minal Vasanawala¹, and Michael Zeineh¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Neurology, Stanford University, Stanford, CA, United States

Hippocampal subfields are selectively affected in AD, however the hippocampus is assessed as a whole in PET studies. In this work we investigate the metabolic, perfusion and diffusion changes within the subfields of patients with MCI and AD using a simultaneous PET-MR scanner. Our preliminary results demonstrate significant reduction in metabolism and perfusion that are appreciated on the subfield level but not when assessing the hippocampus as a whole. This work suggests that subfield assessment is potentially more sensitive to pathological changes in AD than whole hippocampus analysis, and highlights the utility of simultaneous PET-MR as a tool for discovering novel biomarkers in neurodegenerative diseases.

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