Abstract #1265

Regional CBF and Cognition in Longitudinal ADNI Disease Groups

Sudipto Dolui^1,2, Long Xie^3,4, David A. Wolk², and John A. Detre^1,2

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ³Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States

We evaluated longitudinal changes in regional cerebral blood flow (CBF) for patients at different stages of Alzheimer’s disease and correlated CBF with cognition assessed by the clinical dementia rating scale sum of boxes (CDR-SB). Mean CBF in precuneus, posterior cingulate cortex (PCC) and hippocampus were statistically significantly correlated with CDR-SB. However, longitudinal changes in CDR-SB only correlated with CBF change in PCC. There was a statistically significant group difference in baseline PCC-CBF between incipient Alzheimer’s patients whose cognitive function deteriorated versus those who didn’t, demonstrating that CBF can be used as a predictor of disease progression.

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