Meeting Banner
Abstract #1266

The effect of the medical food Souvenaid on brain phospholipid metabolism in patients with mild Alzheimer’s disease: a randomised controlled 31P-MRS study

Anne Rijpma1,2, Marinette van der Graaf3,4, Olga Meulenbroek1,2, Marieke Lansbergen5, John Sijben5, Marcel Olde Rikkert1,2, and Arend Heerschap3

1Geriatric Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, Netherlands, 3Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 4Paediatrics, Radboud university medical center, Nijmegen, Netherlands, 5Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, Netherlands

Loss of neuronal membranes and synaptic integrity are major factors that contribute to the development of cognitive impairment in individuals with Alzheimer’s disease (AD). Membrane phospholipid metabolism can be investigated non-invasively using phosphorus Magnetic Resonance Spectroscopy (31P-MRS). Here we report on the results of a double-blind randomised controlled study investigating the effects of the medical food Souvenaid on brain phospholipid metabolism in patients with mild AD. 3D 31P-MRS imaging was performed at baseline and after 4 weeks intervention.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract