Abstract #1266

The effect of the medical food Souvenaid on brain phospholipid metabolism in patients with mild Alzheimer’s disease: a randomised controlled 31P-MRS study

Anne Rijpma^1,2, Marinette van der Graaf^3,4, Olga Meulenbroek^1,2, Marieke Lansbergen⁵, John Sijben⁵, Marcel Olde Rikkert^1,2, and Arend Heerschap³

¹Geriatric Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, Netherlands, ³Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ⁴Paediatrics, Radboud university medical center, Nijmegen, Netherlands, ⁵Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, Netherlands

Loss of neuronal membranes and synaptic integrity are major factors that contribute to the development of cognitive impairment in individuals with Alzheimer’s disease (AD). Membrane phospholipid metabolism can be investigated non-invasively using phosphorus Magnetic Resonance Spectroscopy (³¹P-MRS). Here we report on the results of a double-blind randomised controlled study investigating the effects of the medical food Souvenaid on brain phospholipid metabolism in patients with mild AD. 3D³¹P-MRS imaging was performed at baseline and after 4 weeks intervention.

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