Abstract #1271

Profiling patterns of white matter injury in normal pressure hydrocephalus pre- and post-intervention using diffusion tensor imaging

Nicole Chwee Har Keong^1,2, Alonso Pena³, Stephen J Price⁴, Marek Czosnyka⁴, Zofia Czosnyka⁴, Elise DeVito⁵, Charlotte Housden⁶, Jonathan H Gillard⁷, Barbara Sahakian⁶, and John D Pickard⁴

¹Neurosurgery, National Neuroscience Institute, Singapore, Singapore, ²Neurosurgery, University of Cambridge, Cambridge, United Kingdom, ³SDA Bocconi School of Management, Milan, Italy, ⁴Neurosurgical Division, Dept of Clinical Neurosciences, University of Cambridge Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ⁵Dept of Psychiatry, Yale University School of Medicine, New Haven, CT, United States, ⁶Department of Psychiatry and MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom, ⁷Department of Radiology, University of Cambridge, Cambridge, United Kingdom

Normal pressure hydrocephalus (NPH) is a confounding condition of gait disturbance, cognitive decline and urinary incontinence remediable with surgical intervention. We have used diffusion tensor imaging (DTI) to demonstrate patterns of white matter injury pre- and post-surgical intervention

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