Abstract #1272

Quantifying the effects of age and the apolipoprotein E ε4 allele on Alzheimer’s disease progression

Hao Shu¹, Guangyu Chen¹, Gang Chen¹, B. Douglas Ward¹, Piero G. Antuono², and Shi-Jiang Li¹

¹Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ²Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States

Aging and the apolipoprotein E (APOE) ε4 allele are two established factors advancing Alzheimer’s disease (AD) progression; however, the extent to which these factors effect AD remains unclear. In this study, we employed the event-based probabilistic model to develop an index for characterizing Alzheimer’s disease risk event (CARE); we then used the CARE index to quantify the effects of age and the APOE ε4 allele on AD progression. This study demonstrated an aging-related increase in CARE index scores and its exacerbation by the APOE ε4 allele, thus providing a surrogate to quantitatively assess aging and the APOE ε4 allele modulations on AD progression.

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