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Abstract #1273

Dissecting the Role of Gender in Alzheimer's Disease: A 1H-[13C]-NMR Study in APP-PS1 Mice

Anant Bahadur Patel1, Niharika Rajnala1, and Kamal Saba1

1NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

The population of Alzheimer's disease (AD) is increasing due to increased longevity in human. The dementing condition associated with AD is reported to be more in female than male. In this study, we explored the neurotransmitter metabolism in APP-PS1 female mice, and compared with age matched males, using 1H-[13C]-NMR spectroscopy following an administration of [1,6-13C2]glucose. The cerebral metabolic rates of glucose oxidation by glutamatergic and GABAergic neurons was found to be reduced in the cerebral cortex, striatum and hippocampus of the transgenic male mice. In contrary, transgenic female mice did not show change in metabolic rates when compared with wild type controls.

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