Abstract #1274

Analysis of Functional Connectivity between Hippocampus Subfields and Perirhnial / Parahippocampal in patient with Mild Cognitive Impairment and Alzheimer’s Disease

Yafei Wang¹, Yu Sun¹, Lingyi Xu¹, Yue Zhang¹, Jiaming Lu², Bing Liu³, Bing Zhang², and Suiren Wan¹

¹The Laboratory for Medical Electronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China, People's Republic of, ²Department of Radiology, The affiliated Drum Tower hospital of Nanjing University Medical School, Nanjing, China, People's Republic of, ³National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Science, Beijing, China, People's Republic of

The functional connectivity between hippocampus subfields and perirhnial cortices (PRC)/parahippocampal cortices (PHC) among normal cognition controls (NC), mild cognitive impairment (MCI) and Alzheimer’s disease (AD) was investigated in this study. The result shows the significant differences of functional connectivity in 3 pairs of ROIs among NC, AD and MCI. It may reveal that the difference of functional connectivity can be the marker to diagnosis AD and MCI.

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